Rahul Majumdar

STAMFORD, Conn. – March 25, 2021 – Avrio Health L.P., a subsidiary of Purdue Pharma L.P., today announced the launch of two Senokot® Dietary Supplement Products: Senokot Laxative* Gummies – Blueberry Pomegranate flavor, and Senokot Laxative* Tea.

Senokot Dietary Supplement Laxative* Gummies – Blueberry Pomegranate flavor is a new flavor of Senokot Laxative* Gummies for gentle overnight relief of occasional constipation. ^†* Made from a natural senna plant, Senokot Laxative* Gummies are for occasional constipation relief.* This product is available online now, and in retail stores in June.

Senokot Dietary Supplement Laxative* Tea is a blend of natural and organic senna and chamomile that offers a sweet flavor with subtle cinnamon and floral notes. Relax with a cup before bedtime to provide overnight relief of occasional constipation. ^†* This product is available online in April and in retail stores in June.

These two products exemplify the ways in which Avrio Health continues to strengthen its core brand, Senokot.

^†When taken at bedtime
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Additional Information

If pregnant, nursing or taking any medications, consult a healthcare professional before use. Do not take this product if you are allergic to any of the ingredients. Keep out of reach of children. In case of accidental overdose, seek professional assistance or contact a Poison Control Center immediately.

Do not exceed the recommended amount or use this supplement for longer than 1 week unless directed by a doctor. Read the full product label before using.

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About Avrio Health L.P.
Avrio Health L.P., a subsidiary of Purdue Pharma L.P., is a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions. We have a strong portfolio of well-respected and proven effective brands, including Betadine^®, Colace^®, Senokot^®, and SlowMag® Mg.

About Purdue Pharma L.P.
Purdue Pharma and its subsidiaries are physician-founded and physician-led companies that develop, manufacture and market medications and consumer health products to meet the evolving needs of healthcare professionals, patients, consumers and caregivers. Purdue Pharma is also committed to driving innovations in patient care while continuing our efforts to address the opioid crisis.

Purdue’s subsidiaries include: Adlon Therapeutics L.P., focused on treatment options for Attention-Deficit/Hyperactivity Disorder (ADHD) and related disorders; Avrio Health L.P., a consumer wellness company that provides over-the-counter products to fight infection, promote digestive wellness and provide health supplements; Imbrium Therapeutics L.P., established to develop and commercialize non-opioid pain medications and therapies for select oncology and CNS disorders; Rhodes Pharmaceuticals L.P., which develops and supplies primarily solid oral-dose and transdermal medications; and Greenfield Bioventures L.P., an investment vehicle focused on compounds in the early stages of clinical development.

For more information, visit www.purduepharma.com.

Media Contact:
Michele Sharp
michele.sharp@pharma.com
(203) 585-3195

STAMFORD, Conn. – February 08, 2021 – Avrio Health L.P. (Avrio), a subsidiary of Purdue Pharma L.P. (Purdue), today announced the launch of new Betadine^® Antiseptic Oral Rinse (active ingredient 0.5% povidone-iodine, or PVP-I), an oral antiseptic pre-procedural rinse. The product is for professional use only, and is not for retail sale. The Oral Rinse is available through your local dental distributor.

Betadine antiseptic products have been used in the hospital and outpatient settings for their antiseptic (antimicrobial) properties for more than 50 years.

Betadine^® Antiseptic Oral Rinse should be administered by professionals and used orally (do not swallow) in preparation of the oral mucosa prior to injection, dental surgery, or tooth extraction. Do not use this product for more than 7 days unless directed by a dentist or doctor. Do not use this product in children under 12 years of age unless directed by a dentist or doctor. Do not use this product if you are allergic to povidone-iodine or any other ingredients in this product, or if you have any thyroid conditions. For more information, visit www.Betadine.com.

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About Betadine
Betadine Topical Antiseptic products have been used in the hospital and outpatient setting for their antimicrobial properties for more than 50 years. Betadine Topical Antiseptic products currently available in the U.S. are for external use only and should not be gargled or swallowed. Use only as directed on the label. Betadine Sore Throat Gargle (0.5% povidone-iodine antiseptic gargle), which should not be ingested, is used for the temporary relief of sore throat.

About Avrio Health L.P.
Avrio Health L.P., a subsidiary of Purdue Pharma L.P., is a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions. We have a strong portfolio of well-respected and proven effective brands, including Betadine^®, Colace^®, Senokot^®, and SlowMag™ Mg.

About Purdue Pharma L.P.
Purdue Pharma and its subsidiaries are physician-founded and physician-led companies that develop, manufacture and market medications and consumer health products to meet the evolving needs of healthcare professionals, patients, consumers and caregivers. Purdue Pharma is also committed to driving innovations in patient care while continuing our efforts to address the opioid crisis.

Purdue’s subsidiaries include: Adlon Therapeutics L.P., focused on treatment options for Attention-Deficit/Hyperactivity Disorder (ADHD) and related disorders; Avrio Health L.P., a consumer wellness company that provides over-the-counter products to fight infection, promote digestive wellness and provide health supplements; Imbrium Therapeutics L.P., established to develop and commercialize non-opioid pain medications and therapies for select oncology and CNS disorders; Rhodes Pharmaceuticals L.P., which develops and supplies primarily solid oral-dose and transdermal medications; and Greenfield Bioventures L.P., an investment vehicle focused on compounds in the early stages of clinical development.

For more information, visit www.purduepharma.com.

Media Contact:
Michele Sharp
michele.sharp@pharma.com
(203) 585-3195

STAMFORD, Conn. – August 13, 2020 – Avrio Health L.P., a subsidiary of Purdue Pharma L.P. (“Purdue”), is reporting encouraging preliminary results of an in vitro (laboratory) study assessing Betadine® Antiseptic Sore Throat Gargle (active ingredient, povidone-iodine or “PVP-I”) against the virus causing COVID-19. Preliminary results show Betadine Gargle killed 99.9 percent of the virus within 15 seconds.

Betadine Gargle containing 0.5% PVP-I demonstrated virucidal activity against SARS-CoV-2 and four surrogate coronaviruses in three separate in vitro studies. An in vitro study conducted by Utah State University, Institute for Antiviral Research, assessed virucidal activity of Betadine Gargle against SARS-CoV-2. In this study, results showed a 99.9 percent reduction of SARS-CoV-2 viral load starting at 15 seconds and at all subsequent time points in the study (30 seconds, 60 seconds and 5 minutes).

Betadine Gargle was also studied against surrogate coronaviruses: Murine Hepatitis Virus Strain A59, a betacoronavirus within the subfamily Coronavirus, in a second study conducted by BluTest Laboratories, as well as human coronaviruses strains OC43 (alphacoronavirus), NL63 (alphacoronavirus), and 229E (betacoronavirus) in a third study conducted by Bioscience Laboratories. These two studies were conducted under ASTM E-1052- methods for measuring virucidal time kill to assess the activity of microbicides against viruses. In these two studies, results showed a 99.9 percent reduction in viral load starting at 15 seconds and at all subsequent time points (30 seconds, 60 seconds and 5 minutes).

“We are encouraged by these data as we continue to study PVP-I’s potential virucidal properties against the SARS-CoV-2 virus,” said Craig Landau, MD, president and CEO, Purdue Pharma. “Purdue and Avrio Health are committed to leveraging science to address public health needs, and to provide support during this uncharted public health emergency.”

Next, In vivo (human) studies will assess the safety and effectiveness of Betadine Gargle against SARS-CoV-2. Additionally, tests are being conducted on other Betadine formulations, as part of a comprehensive research program assessing the safety and effectiveness of Betadine Antiseptic products (Topical and Gargle) against COVID-19 that began in May.

Other studies on distinct international formulation:
Separately, in vitro studies conducted by the Tropical Infectious Diseases Research and Education Center at the University of Malaya, Malaysia, and at the Duke-NUS Medical School in Singapore, on a separate and distinct formulation of Betadine Gargle available abroad – but not in the U.S. –  found that formulation of Betadine® Gargle (tested at 0.5% and 1.0% PVP-I) killed 99.99% of SARS-CoV-2 at the first timepoints measured.^1,2

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About Betadine
Betadine Topical Antiseptic products have been used in the hospital and outpatient setting for their antimicrobial properties for more than 50 years. Betadine Topical Antiseptic products currently available in the U.S. are for external use only and should not be gargled or swallowed.  Betadine Antiseptic Sore Throat Gargle (0.5% povidone-iodine antiseptic gargle), which should not be swallowed, is an oral antiseptic with use for the temporary relief of occasional sore throat. Betadine Antiseptic Sore Throat Gargle will be available in retail stores in late August 2020. All products should be used only as directed on the label.

About Avrio Health L.P.
Avrio Health L.P., a subsidiary of Purdue Pharma L.P., is a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions. We have a strong portfolio of well-respected and proven effective brands, including Betadine®, Colace®, Senokot®, and SlowMag™ Mg.

About Purdue Pharma L.P.
Purdue Pharma and its subsidiaries develop and provide prescription medicines and consumer products that meet the evolving needs of healthcare professionals, patients, consumers and caregivers. We were founded by physicians and are currently led by a physician. Beyond our efforts to provide quality medications, Purdue Pharma is committed to supporting national, regional and local collaborations to drive innovations in patient care while also continuing our efforts to address the opioid crisis.

Purdue’s subsidiaries include: Adlon Therapeutics L.P., focused on treatment for Attention-Deficit/Hyperactivity Disorder (ADHD) and related disorders; Avrio Health L.P., a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions; Imbrium Therapeutics L.P., established to further advance the emerging portfolio and develop the pipeline in the areas of CNS, non-opioid pain medicines, and select oncology through internal research, strategic collaborations and partnerships; and Greenfield Bioventures L.P., an investment vehicle focused on value-inflection in early stages of clinical development.

For more information, visit www.purduepharma.com.

Media Contact:
Michele Sharp

¹ Anderson, D.E., Sivalingam, V., Kang, A.E.Z. et al. Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease. Infect Dis Ther (2020). https://doi.org/10.1007/s40121-020-00316-3
² Hassandarvish, P., Tiong, V., Sazaly, A. et al. Povidone iodine gargle and mouthwash . Br Dent J 228, 900 (2020). https://doi.org/10.1038/s41415-020-1794-1

STAMFORD, Conn. – August 11, 2020 – Avrio Health L.P. (Avrio), a subsidiary of Purdue Pharma L.P. (Purdue), today announced the launch of new Betadine^® Antiseptic Sore Throat Gargle (active ingredient povidone-iodine, or PVP-I), an oral antiseptic with use for the temporary relief of occasional sore throat.

This new gargle, which will be available in retail stores in late August, joins the Betadine family of topical antiseptic products that help to protect against germs and prevent infection in minor cuts, scrapes and burns. Betadine antiseptic products have been used in the hospital and outpatient setting for their antiseptic (antimicrobial) properties for more than 50 years.

Betadine Antiseptic Sore Throat Gargle should be used orally (do not swallow) for the temporary relief of occasional sore throat. It may be used at the first sign of a sore throat. The product can be used up to four times daily as directed on the label.

Betadine Antiseptic Sore Throat Gargle can be used by adults and children 12 years of age and older. Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious. Consult a doctor promptly. Do not use more than 2 days or administer to children under 3 years of age unless directed by a doctor. Do not use this product if you are allergic to povidone-iodine or any other ingredients in this product, or if you have any thyroid conditions. For more information, visit www.Betadine.com.

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About Betadine

Betadine Topical Antiseptic products have been used in the hospital and outpatient setting for their antimicrobial properties for more than 50 years. Betadine Topical Antiseptic products currently available in the U.S. are for external use only and should not be gargled or swallowed. Use only as directed on the label. Betadine Sore Throat Gargle (0.5% povidone-iodine antiseptic gargle), which should not be ingested, relieves sore throat.

About Avrio Health L.P.

Avrio Health L.P., a subsidiary of Purdue Pharma L.P., is a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions. We have a strong portfolio of well-respected and proven effective brands, including Betadine^®, Colace^®, Senokot^®, and SlowMag™ Mg.

About Purdue Pharma L.P.

Purdue Pharma and its subsidiaries develop and provide prescription medicines and consumer products that meet the evolving needs of healthcare professionals, patients, consumers and caregivers. We were founded by physicians and are currently led by a physician. Beyond our efforts to provide quality medications, Purdue Pharma is committed to supporting national, regional and local collaborations to drive innovations in patient care while also continuing our efforts to address the opioid crisis.

Purdue’s subsidiaries include: Adlon Therapeutics L.P., focused on treatment for Attention-Deficit/Hyperactivity Disorder (ADHD) and related disorders; Avrio Health L.P., a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions; Imbrium Therapeutics L.P., established to further advance the emerging portfolio and develop the pipeline in the areas of CNS, non-opioid pain medicines, and select oncology through internal research, strategic collaborations and partnerships; and Greenfield Bioventures L.P., an investment vehicle focused on value-inflection in early stages of clinical development.

For more information, visit www.purduepharma.com.

Media Contact:

Michele Sharp

michele.sharp@pharma.com

(203) 585-3195

 STAMFORD, Conn. – July 16, 2020 – Avrio Health L.P. (“Avrio”), a subsidiary of Purdue Pharma L.P. (“Purdue”), has donated shipments of Betadine Solution and Surgical Scrub to Direct Relief, advancing the company’s previous commitment to donate $1.6 million worth of Betadine antiseptic products (active ingredient, povidone-iodine or “PVP-I”) for use by frontline healthcare workers.

Betadine Solution and Betadine Surgical Scrub are antiseptic products for healthcare professionals to use to reduce the number of microorganisms on the skin that can potentially cause infection. Betadine antiseptic products have been used by healthcare professionals for more than 50 years. This donation follows previous product donations to New York State and Connecticut.

“We have supported Direct Relief both recently and historically with a COVID-19 special donation grant and product donations tied to hurricane relief efforts. We are thankful for the organization’s leadership and ingenuity during current and past health and humanitarian crises,” said Craig Landau, MD, president and CEO, Purdue Pharma. “Avrio’s latest donations are part of our ongoing efforts to support healthcare workers on the front lines as they continue to serve people in need during this pandemic.”

Purdue will continue to work with various interested parties and organizations, including state health officials and public health experts, to determine where future shipments of Betadine antiseptic products are most needed.

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About Avrio Health L.P.

Avrio Health L.P., a subsidiary of Purdue Pharma L.P., is a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions. We have a strong portfolio of well-respected and proven effective brands, including Betadine^®, Colace^®, Senokot^®, and SlowMag™ Mg.

About Purdue Pharma L.P.

Purdue Pharma and its subsidiaries develop and provide prescription medicines and consumer products that meet the evolving needs of healthcare professionals, patients, consumers and caregivers. We were founded by physicians and are currently led by a physician. Beyond our efforts to provide quality medications, Purdue Pharma is committed to supporting national, regional and local collaborations to drive innovations in patient care while also continuing our efforts to address the opioid crisis.

Purdue’s subsidiaries include: Adlon Therapeutics L.P., focused on treatment for Attention-Deficit/Hyperactivity Disorder (ADHD) and related disorders; Avrio Health L.P., a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions; Imbrium Therapeutics L.P., established to further advance the emerging portfolio and develop the pipeline in the areas of CNS, non-opioid pain medicines, and select oncology through internal research, strategic collaborations and partnerships; and Greenfield Bioventures L.P., an investment vehicle focused on value-inflection in early stages of clinical development.

For more information, visit www.purduepharma.com.

About Direct Relief 

A humanitarian organization committed to improving the health and lives of people affected by poverty or emergencies, Direct Relief delivers lifesaving medical resources throughout the world to communities in need—without regard to politics, religion, or ability to pay. For more information, please visit https://www.DirectRelief.org.

Media Contact:

Michele Sharp

michele.sharp@pharma.com

(203) 585-3195

STAMFORD, Conn. – May 19, 2020 – Avrio Health L.P., a subsidiary of Purdue Pharma L.P. (“Purdue”), has initiated a program to evaluate the potential safety and virucidal effectiveness of certain formulations of Betadine® antiseptic products (active ingredient, povidone-iodine or “PVP-I”) against the virus causing COVID-19. An in vitro study evaluating activity against a surrogate coronavirus has begun, with additional in vitro and in vivo studies planned to evaluate certain formulations of Betadine antiseptic products.

Betadine antiseptic products are used to reduce the number of microorganisms on the skin that can potentially cause infection. Some of these products have been used by healthcare professionals for more than 50 years.

“Our Purdue and Avrio Health teams are passionate about contributing potential solutions that target COVID-19,” said Craig Landau, MD, president and CEO, Purdue Pharma. “We’re encouraged by emerging data, as well as the considerable published, peer-reviewed in vitro data that are available against other viruses in the coronavirus-family. Specifically, products containing PVP-I have previously demonstrated virucidal activity^1,2,3,4,5 in a laboratory setting against other coronaviruses, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS).”

“While more data are needed, these in vitro data, combined with the recognized need for effective measures to prevent infection, support our decision to pursue our own fulsome research program. This initiative is a true reflection of our longstanding commitment to bringing important therapies forward at times of great need.”

Healthcare professionals, including nurses, doctors, respiratory therapists, EMTs and many others, have a markedly higher risk of becoming infected with COVID-19, especially if they are exposed to a high volume of sick patients (such as in the emergency room) or respiratory secretions (such as in the intensive care unit).⁶ Latest data from CDC indicate that more than 9,000 healthcare personnel have contracted COVID-19.⁷ In addition, continuous and often sustained exposure to COVID-19 positive patients represents significant risk to caregivers, their families, as well as non-infected patients.^6,8

Consistent with the ongoing U.S. Food and Drug Administration procedures for the evaluation of OTC antiseptic drug products, including those containing povidone-iodine, Betadine antiseptic products are available for use as labeled while additional data from these proposed studies are being generated.⁹

This release discusses investigational uses of Betadine and is not intended to convey conclusions about its efficacy or safety in reducing COVID-19 or any other viruses. Betadine antiseptic products have not been demonstrated to be effective against COVID-19 or any other viruses, nor have any clinical studies been conducted to assess its safety or effectiveness as a virucidal agent. There is no guarantee that studies evaluating the effectiveness of povidone-iodine against the virus causing COVID-19 will be successful.

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About Betadine

Betadine Topical Antiseptic products have been used in the hospital and outpatient setting for their antimicrobial properties for more than 50 years. Betadine Topical Antiseptic products currently available in the U.S. are for external use only and should not be gargled or swallowed. Use only as directed on the label.

About Avrio Health L.P.

 Avrio Health L.P., a subsidiary of Purdue Pharma L.P., is a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions. We have a strong portfolio of well-respected and proven effective brands, including Betadine®, Colace®, Senokot®, and SlowMag™ Mg.

About Purdue Pharma L.P.

Purdue Pharma and its subsidiaries develop and provide prescription medicines and consumer products that meet the evolving needs of healthcare professionals, patients, consumers and caregivers. We were founded by physicians and are currently led by a physician. Beyond our efforts to provide quality medications, Purdue Pharma is committed to supporting national, regional and local collaborations to drive innovations in patient care while also continuing our efforts to address the opioid crisis.

Purdue’s subsidiaries include: Adlon Therapeutics L.P., focused on treatment for Attention-Deficit/Hyperactivity Disorder (ADHD) and related disorders; Avrio Health L.P., a consumer health products company that champions an improved quality of life for people in the United States through the reimagining of innovative product solutions; Imbrium Therapeutics L.P., established to further advance the emerging portfolio and develop the pipeline in the areas of CNS, non-opioid pain medicines, and select oncology through internal research, strategic collaborations and partnerships; and Greenfield Bioventures L.P., an investment vehicle focused on value-inflection in early stages of clinical development.

For more information, visit www.purduepharma.com.

Media Contact:

Michele Sharp
michele.sharp@pharma.com
(203) 585-3195

¹ Eggers M, Eickmann M, Kowalski K, Zorn J, Reimer K. Povidone-iodine hand wash and hand rub products demonstrated excellent in vitro virucidal efficacy against Ebola virus and modified vaccinia virus Ankara, the new European test virus for enveloped viruses. BMC Infect Dis. 2015;15:375.

² Eggers M, Eickmann M, Zorn J. Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus Ankara (MVA). Infect Dis Ther. 2015;4:491–501.

³ Eggers M, Koburger-Janssen T, Eickmann M, Zorn J. In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens. Infect Dis Ther 2018;7:249–259.

⁴ Kariwa H, Fujii N, Takashima I. Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents. Dermatology. 2006;212(Suppl 1):119–123.

⁵ Kawana R, Kitamura T, Nakagomi O, et al. Inactivation of human viruses by povidone-iodine in comparison with other antiseptics. Dermatology. 1997;195(suppl 2):29-35.

⁶ Harvard Health Blog, Harvard Medical School. What’s it like to be a healthcare worker in a pandemic? 2020. Accessed April 20, 2020. Retrieved from https://www.health.harvard.edu/blog/whats-it-like-to-be-a-healthcare-worker-in-a-pandemic-2020040819485.

⁷ Centers for Disease Control and Prevention (CDC). Characteristics of Health Care Personnel with COVID-19 — United States, February 12–April 9, 2020. MMWR Morb Mortal Wkly Rep 2020;69:477–481.

⁸ Centers for Disease Control and Prevention (CDC). Interim U.S. Guidance for Risk Assessment and Public Health Management of Healthcare Personnel with Potential Exposure in a Healthcare Setting to Patients with Coronavirus Disease 2019 (COVID-19). 2020. Accessed April 20, 2020. Retrieved from https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.html.

⁹ U.S. Food and Drug Administration (FDA). Safety and Effectiveness of Health Care Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use. 2017. Accessed April 20, 2020. Retrieved from https://www.federalregister.gov/documents/2017/12/20/2017-27317/safety-and-effectiveness-of-health-care-antiseptics-topical-antimicrobial-drug-products-for.